The role of ripc in preventing organ damage, inflammation and oxidative stress during lower limb DSA: A randomised controlled trial

Background and Aims : Diagnostic digital subtraction angiography (DSA) DSA with percutaneous transluminal angioplasty (DSA-PTA) are common procedures for diagnosing treating symptomatic lower extremity arterial disease (LEAD). However, organ damage following DSA-PTA is often under-recognised hence undiagnosed. The aim of the current study was to assess effect remote ischemic preconditioning (RIPC) intervention on markers profile, oxidative stress inflammation biomarkers in LEAD patients undergoing procedure.Methods: RIPC performed by inflating a standard blood pressure cuff patient's upper arm 200 mmHg 5 minutes four times 5-minute perfusion between each cycle. sham similarly, but inflated 20 mmHg.Results: A total 111 (RIPC 54, 57) scheduled endovascular procedure were randomized, 102 47, 55) completed protocol. significantly limited increase adiponectine levels after DSA-PTA, compared (p=0.020), CK-MB markedly group (p=0.047) procedure. There no significant difference mean changes hs-Troponin-T (p=0.25), NT-proBNP (p=0.24), creatinine (p=0.76), eGFR (p=0.61), urea (p=0.95), beta-2-microglobuline (p=0.34) or cystatine C (p=0.24) levels.Conclusions: In this controlled clinical failed improve profile renal cardiac periprocedurally. limits rise adiponectin may influence decrease levels. Methods: mmHg. Results: Conclusions: